As soon as you enter Quebec City, either by Highway 20 or Highway 40, there are road signs indicating the way to Sainte-Anne-de-Beaupré.

Once you have driven through Quebec City, you have two options:

- You can take Boulevard Sainte-Anne (highway 138). You will arrive in Sainte-Anne-de-Beaupré in about 25 minutes. 
- You can take Avenue Royale (Route de la Nouvelle France / Chemin du Roi), one of the oldest roads in Canada. It will take you a little longer to arrive, but it's worth it!